Nequinate

Product: Nequinate Methylbenzoquate
CAS NO: 13997-19-8
Molecular Formula: C22H23NO4
Molecular Weight: 365.42
Character: White or sandy beige powders, innocuity
Melting point: 286-289℃.
Assay: (by HPLC)：≥97.0 %

This product quinoline anticoccidial drugs, such has been the commercialization of anticoccidial drugs are: Ding hydroxy quinoline (Byqyuni late D quinoline), B hydroxy quinoline (Decoquinate to be quinoline ester, decyl ester quinoline , decyl ester oxygen quinoline), a benzyl quinoline (Methylbenzoquate methyl benzene quinoline ester, benzyl ester quinoline) three. The activity of this class of drugs is a ball sporozoites peak period (cycle day 1), the first day of exposure to coccidiosis fed dosing feed to get the maximum effect. Doses that inhibit the animals to prevent coccidiosis own immunity. As anticoccidial obvious, and more recommended for broilers. Hydroxy quinoline and clopidol similar structure, but no cross-resistance between the two, mixed with a synergistic effect (synergy). Less absorption of the medicines, low toxicity, tissue residues less broiler feed the whole of the add, for the prevention of coccidiosis, the withdrawal of 3 days. Add the amount of feed (broiler): HTPB Hao Lin: 82.5g / t; b hydroxy quinoline: 20 ~ 30g / t; a benzyl quinoline: 20g / t.

Trimethoprim anticoccidial effect of quinoline strong is quinoline hydroxy quinoline drugs in the double B, D oxygen quinoline 10 times. If the goods to 5 mg / kg feed mixed feeding, the antibacterial effect of the equivalent of insects Amprolium 62.5 mg / kg feed and the ball dysentery Ling 125 mg / kg feed effect.

Properties: white or light brown, insoluble in water, so the anticoccidial effects associated with the powder particle size, the smaller the role of particles as possible, so generally made of 1.8-micron-sized particles application.

Function and Use: anticoccidial effect may interfere with DNA and synthesis of insect body. Can prevent the chicken cecum, poisoning, reactor type, Brinell, and several tenella, the role of the peak of the first day after infection, the main inhibiting asexual reproduction of the first generation of coccidia sporophyte growth and reproduction, the eggs in the host infection better day capsule dosing. Oral absorption of the product less toxicity, low residue. Completely inhibited oocyst production because of the difficulty, it is easy to produce drug resistance, and will inhibit the body's immune system, which application is limited. Mainly used for broilers.

Preparation, dosage: Often used in the powder. The amount of mixed feed of 20 mg / kg feed. The mixture with chlorine hydroxy pyrimidine (chloro hydroxy quinoline pyrimidine ten toluene) chicken, rabbit feed dosage: 10.0g / t +8.5 g / t coccidia of the medicines is easy to produce drug resistance, is currently used as a short-term multi-drug use.

Third, product market

This product is Ayerst development and production of the specific listing of which year is unknown. But when in 1971 as a feed additive in 1978, had applied for FDA registration, products and trimethoprim Roxarsone quinoline compound or oxytetracycline, but not ratified. Ayerst Laboratories is now no longer produced the product. Little information about the products, domestic manufacturers may not.

Fourth, product patents and technologies

The product patent for the British patent, 1966. Pan-China Branch of Zhejiang University Chemical Co., Ltd. has successfully developed the production technology, the content is 98.0%.